GHK-CU 50mg

GHK Cu

50mg per vial

Synonym:  (Gly-His-Lys)2Cu.xHAc

A tripeptide first noticed in human blood. Also known as a ‘metallopeptide’ due to the copper molecules attached to it. GHK levels have been shown to drop with age, leading to reduced healing, skin elasticity, immune system function, overall regeneration, antioxidant capacity and promotion of blood vessel growth.

The list of proven benefits of GHK Cu on cellular function and biology is long:

Hair growth benefit: GHK-Cu and its cousins were found to strongly stimulate hair growth. The efficiency of synthetic analog of GHK-Cu was similar to that of 5% minoxidil.

Anti-cancer effects: In 2010, Hong Y. et al. (Department of Colorectal Surgery, Singapore General Hospital, Singapore) demonstrated that GHK-Cu is able to reverse the expression of certain genes involved in metastatic spreading of colon cancer. GHK-Cu was effective at a very low concentration. The fact that GHK was able to suppress 70% of genes involved in the development of an aggressive metastatic form of colon cancer indicates that GHK is capable of the regulation of various biochemical pathways on a gene level and it seems to be resetting the gene activity back to health, which leads to the improvement of tissue repair.

Stem cells: In 2009, a group of researchers from the Seoul National University (Republic of Korea) demonstrated that the copper-peptide GHK-Cu stimulated proliferation of keratinocytes and increased expression of integrins and p63 protein in the epidermal stem cells. Since p63 is considered to be an important marker of stem cell and anti-senescence protein, the authors concluded that GHK-copper is able to revive the proliferative potential of epidermal stem cells and increase their ability to repair tissue.

Nerve regeneration: In 2005, Ahmed et al. demonstrated that GHK promotes nerve regeneration. Axon regeneration was studied using collagen tubes with incorporated peptides. GHK increased the production of nerve growth factors, expression of integrins and increased the rate of regeneration of myelinated nerve fibers.

Human fibroblasts: Recent studies have revealed many new aspects of molecular actions of the copper-peptide GHK-Cu. Pollard at al established that GHK-Cu is able to restore function of human fibroblasts damaged by radiation treatment thus accelerating the healing and regenerative processes.

Skin repair: Wound healing and skin repair involves inflammation, cell proliferation and migration and dermal matrix remodeling. Excessive inflammation may delay healing and lead to scar formation. GHK-Cu reduced TNF-alpha induced secretion of proinflammatory cytokine IL-6, 

Dna repair: GHK was able to restore viability of irradiated fibroblasts. 

It has long been accepted that the human copper-binding peptide GHK-Cu enhances healing of dermal wounds and stimulates skin renewal exhibiting a wide range of effects. Cellular pathways involved in dermal repair and skin regeneration form an intricate and finely orchestrated biochemical network, where various regulatory molecules are involved in a cross-talk. When such an interaction is disrupted, the healing is delayed and may result in excessive inflammation and scarring. It appears that GHK is able to restore healthy functioning of essential cellular pathways in dermal repair through resetting the gene pattern to a healthier state. The molecule is very safe and no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies.

Stability:

Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

Source: Biosynthesis

Usage: 

Product is prepared for LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

References:

Pickart, L (2008). "The human tri-peptide GHK and tissue remodeling". J. Biomater. Sci. Polymer Edn. 19 (8): 969–988. doi:10.1163/156856208784909435. PMID 18644225

 Pickart, L; Thaler, MM (1973). "Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver". Nature New Biology. 243(124): 85–87. PMID 4349963

 Maquart, FX; Pickart, L; Laurent, M; Gillery, P; Monboisse, JC; Borel, JP (1988). "Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+". FEBS Lett. 238 (2): 343–6. doi:10.1016/0014-5793(88)80509-x. PMID 3169264.

Gul, NY; Topal, A; Cangul, IT; Yanik, K (2008). "The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits". Vet Dermatol. 19 (1): 7–14. doi:10.1111/j.1365-3164.2007.00647.x. PMID 18177285.

Gorouhi, F.; Maibach, H.I. (2009). "Role of topical peptides in preventing and treating aged skin". Int. J. Cosm. Sci. 31 (5): 327–345. doi:10.1111/j.1468-2494.2009.00490.x. PMID 19570099