HMG 75IU

Gonadotropins are protein hormones secreted by gonadotrope cells of the anterior pituitary of vertebrates. This is a family of proteins, which include the mammalian hormones Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), placental chorionic gonadotropins hCG and eCG and chorionic gonadotropin (CG). These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function. The hormones LH and FSH are secreted by the anterior pituitary gland, while hCG and eCG are secreted by the placenta.

Synonyms: HMG, Human Menopausal Gonadotropin, Gonadototropins, LH/FSH.

Sequence: 

IUPAC Condensed: 24 kDa LH-α has 92 and LH-β 120 amino acid residues

The 92-amino acid long LH alpha subunit in humans has the following sequence: NH2 – Ala – Pro – Asp – Val – Gln – Asp – Cys – Pro – Glu – Cys – Thr – Leu – Gln – Glu – Asn – Pro – Phe – Phe – Ser – Gln – Pro – Gly – Ala – Pro – Ile – Leu – Gln – Cys – Met – Gly – Cys – Cys – Phe – Ser – Arg – Ala – Tyr – Pro – Thr – Pro – Leu – Arg – Ser – Lys – Lys – Thr – Met – Leu – Val – Gln – Lys – Asn – Val – Thr – Ser – Glu – Ser – Thr – Cys – Cys – Val – Ala – Lys – Ser – Tyr – Asn – Arg – Val – Thr – Val – Met – Gly – Gly – Phe – Lys – Val – Glu – Asn – His – Thr – Ala – Cys – His – Cys – Ser – Thr – Cys – Tyr – Tyr – His – Lys – Ser – OH.

The 120-amino acid long LH beta subunit in humans has the following sequence: NH2 – Ser – Arg – Glu – Pro – Leu – Arg – Pro – Trp – Cys – His – Pro – Ile – Asn – Ala – Ile – Leu – Ala – Val – Glu – Lys – Glu – Gly – Cys – Pro – Val – Cys – Ile – Thr – Val – AsnThr – Thr – Ile – Cys – Ala – Gly – Tyr – Cys – Pro – Thr – Met – Met – Arg – Val – Leu – Gln – Ala – Val – Leu – Pro – Pro – Leu – Pro – Gln – Val – Val – Cys – Thr – Tyr – Arg – Asp – Val – Arg – Phe – Glu – Ser – Ile – Arg – Leu – Pro – Gly – Cys – Pro – Arg – Gly – Val – Asp – Pro – Val – Val – Ser – Phe – Pro – Val – Ala – Leu – Ser – Cys – Arg – Cys – Gly – Pro – Cys – Arg – Arg – Ser – Thr – Ser – Asp – Cys – Gly – Gly – Pro – Lys – Asp – His – Pro – Leu – Thr – Cys – Asp – His – Pro – Gln – Leu – Ser – Gly – Leu – Leu – Phe – Leu – OH

23 kDa FSH-α has 92 and LH-β 111 amino acid residues

The 92-amino-acid-long FSH alpha subunit in humans has the following sequence: NH2 – Ala – Pro – Asp – Val – Gln – Asp – Cys – Pro – Glu – Cys – Thr – Leu – Gln – Glu – Asn – Pro – Phe – Phe – Ser – Gln – Pro – Gly – Ala – Pro – Ile – Leu – Gln – Cys – Met – Gly – Cys – Cys – Phe – Ser – Arg – Ala – Tyr – Pro – Thr – Pro – Leu – Arg – Ser† – Lys – Lys – Thr – Met – Leu – Val – Gln – Lys – Asn – Val – Thr – Ser – Glu – Ser – Thr – Cys – Cys – Val – Ala – Lys – Ser – Tyr – Asn – Arg – Val – Thr – Val – Met – Gly – Gly – Phe – Lys – Val – Glu – Asn – His – Thr – Ala – Cys – His – Cys – Ser – Thr – Cys – Tyr – Tyr – His – Lys – Ser – OH.

The 111-amino-acid-long FSH beta subunit in humans has the following sequence:NH2 – Asn – Ser – Cys – Glu – Leu – Thr – Asn – Ile – Thr – Ile – Ala – Ile – Glu – Lys – Glu – Glu – Cys – Arg – Phe – Cys – Ile – Ser – Ile – Asn – Thr – Thr – Trp – Cys – Ala – Gly – Tyr – Cys – Tyr – Thr – Arg – Asp – Leu – Val – Tyr – Lys – Asp – Pro – Ala – Arg – Pro – Lys – Ile – Gln – Lys – Thr – Cys – Thr – Phe – Lys – Glu – Leu – Val – Tyr – Glu – Thr – Val – Arg – Val – Pro – Gly – Cys – Ala – His – His – Ala – Asp – Ser – Leu – Tyr – Thr – Tyr – Pro – Val – Ala – Thr – Gln – Cys – His – Cys – Gly – Lys – Cys – Asp – Ser – Asp – Ser – Thr – Asp – Cys – Thr – Val – Arg – Gly – Leu – Gly – Pro – Ser – Tyr – Cys – Ser – Phe – Gly – Glu – Met – Lys – Glu – OH

CAS Number: 21888462

PubChem CID: 61489-71-2                                    

Further references

PubChem

Stability: Store lyophilised protein at -20°c. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°c for a limited period of time. The lyophilised protein remains stable until expiry date when stored at -20°c.

Source: Biosynthesis

Reconstitution: Reconstitute with Bacteriostatic Water

Usage: Product is prepared for LABORATORY RESEARCH ONLY. HMG for sale at Pure Peptides UK is limited to scientific research and education only – Only buy HMG if you are a licenced researcher.