Modified GRF (1-29) 2mg (aka CJC-1295 w/o DAC)

Exploring Modified GRF (1-29), also known as CJC-1295 without DAC

Introduction:

In the field of biochemistry, peptides are gaining attention for potential applications in various areas. One such peptide, Modified-GRF, has drawn interest from researchers investigating areas such as anti-aging, muscle growth, and fat loss. This article delves into the specifics of CJC-1295, focusing on the version without DAC (Drug Affinity Complex), its mechanisms, and the current state of research.

Understanding CJC-1295:

CJC-1295 is a synthetic peptide belonging to the growth hormone-releasing hormone (GHRH) category. Its primary function is to stimulate the release of growth hormone (GH) from the pituitary gland. GH plays a crucial role in growth, metabolism, and cellular repair.

The version without DAC is a modified form of CJC-1295 that lacks the DAC component. DAC is typically added to peptides to prolong their half-life, so the version without DAC has a shorter half-life while retaining potency.

Mechanism of Action:

CJC-1295 is believed to act by binding to and activating the growth hormone secretagogue receptor (GHS-R), primarily located in the hypothalamus and pituitary gland. This activation appears to stimulate the release of growth hormone in a pulsatile manner, resembling the natural secretion pattern.

Unlike exogenous growth hormone administration, which can lead to receptor desensitization, Modified-GRF has potential to provide a more physiological approach by regulating endogenous GH release.

Potential Benefits:

The use of Modified-GRF has been associated with several potential benefits, including:

Muscle growth: Growth hormone plays a role in muscle protein synthesis. Via its influence on the release of growth hormone, Modified-GRF could theoretically support muscle growth and repair processes.

Fat loss: Growth hormone has lipolytic effects, meaning it can promote fat breakdown. Modified-GRF’s influence on growth hormone levels may also have implications for body composition. Some research suggests it could affect fat metabolism, potentially influencing factors related to body fat percentage.

Recovery: Growth hormone is known for its tissue-repairing properties. It is speculated that Modified- GRF’s influence on growth hormone levels may help with recovery from injuries or intense physical activity.

Aging: Growth hormone levels decline with age, and Modified-GRF’s ability to affect its release has sparked interest in potential anti-aging effects. While the mechanisms are still being studied, there's speculation that it could contribute to maintaining tissue health and possibly affect aspects of aging.

Research Landscape:

While the potential benefits of Modified-GRF are promising, much of the evidence comes from preclinical studies and academic reports. Clinical research on its efficacy and safety in humans is limited.

Technical details

Synonyms: Mod-GRF (1-29), Modified GRF (1-29), CJC1295 without DAC, 

Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR

IUPAC Condensed: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

Molecular Weight:  3367.95 g/mol

CAS Number: 863288-34-0

PubChem CID: 91976842

Further references

PubChem

Stability: Store lyophilised protein at -20°c. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°c for a limited period of time. The lyophilised protein remains stable until expiry date when stored at -20°c.

Source: Biosynthesis

Reconstitution: Reconstitute with Bacteriostatic Water

Usage: Product is prepared for LABORATORY RESEARCH ONLY. Modified-GRF for sale at Pure Peptides UK is limited to scientific research and education only – Only buy Modified-GRF if you are a licenced researcher.

* Images for illustration purposes only