Premium Modified GRF (1-29) 5mg (aka CJC-1295 w/o DAC)
- Stock: In Stock
- Model: EU-ModGRF-5mg
- Weight: 6.00g
- JAN: Orange>Whi
Exploring Modified GRF (1-29), also known as CJC-1295 without DAC
Introduction:
In the field of biochemistry, peptides are gaining attention for potential applications in various areas. One such peptide, Modified-GRF, has drawn interest from researchers investigating areas such as anti-aging, muscle growth, and fat loss. This article delves into the specifics of CJC-1295, focusing on the version without DAC (Drug Affinity Complex), its mechanisms, and the current state of research.
Understanding CJC-1295:
CJC-1295 is a synthetic peptide belonging to the growth hormone-releasing hormone (GHRH) category. Its primary function is to stimulate the release of growth hormone (GH) from the pituitary gland. GH plays a crucial role in growth, metabolism, and cellular repair.
The version without DAC is a modified form of CJC-1295 that lacks the DAC component. DAC is typically added to peptides to prolong their half-life, so the version without DAC has a shorter half-life while retaining potency.
Mechanism of Action:
CJC-1295 is believed to act by binding to and activating the growth hormone secretagogue receptor (GHS-R), primarily located in the hypothalamus and pituitary gland. This activation appears to stimulate the release of growth hormone in a pulsatile manner, resembling the natural secretion pattern.
Unlike exogenous growth hormone administration, which can lead to receptor desensitization, Modified-GRF has potential to provide a more physiological approach by regulating endogenous GH release.
Potential Benefits:
The use of Modified-GRF has been associated with several potential benefits, including:
Muscle growth: Growth hormone plays a role in muscle protein synthesis. Via its influence on the release of growth hormone, Modified-GRF could theoretically support muscle growth and repair processes.
Fat loss: Growth hormone has lipolytic effects, meaning it can promote fat breakdown. Modified-GRF’s influence on growth hormone levels may also have implications for body composition. Some research suggests it could affect fat metabolism, potentially influencing factors related to body fat percentage.
Recovery: Growth hormone is known for its tissue-repairing properties. It is speculated that Modified- GRF’s influence on growth hormone levels may help with recovery from injuries or intense physical activity.
Aging: Growth hormone levels decline with age, and Modified-GRF’s ability to affect its release has sparked interest in potential anti-aging effects. While the mechanisms are still being studied, there's speculation that it could contribute to maintaining tissue health and possibly affect aspects of aging.
Research Landscape:
While the potential benefits of Modified-GRF are promising, much of the evidence comes from preclinical studies and academic reports. Clinical research on its efficacy and safety in humans is limited.
Technical details
Synonyms: Mod-GRF (1-29), Modified GRF (1-29), CJC1295 without DAC,
Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
IUPAC Condensed: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Molecular Weight: 3367.95 g/mol
CAS Number: 863288-34-0
PubChem CID: 91976842
Further references
Stability: Store lyophilised protein at -20°c. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°c for a limited period of time. The lyophilised protein remains stable until expiry date when stored at -20°c.
Source: Biosynthesis
Reconstitution: Reconstitute with Bacteriostatic Water
Usage: Product is prepared for LABORATORY RESEARCH ONLY. Modified-GRF for sale at Pure Peptides UK is limited to scientific research and education only – Only buy Modified-GRF if you are a licenced researcher.
* Images for illustration purposes only